反应详情

温度

100 °C

A mixture of ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate (3.21 g), 1-(2-pyrimidinyl)piperazine (1.64 g), potassium carbonate (1.38 g) and dimethylformamide (50 ml) is heated at 100° C. for 3 hours, left overnight at room temperature, filtered, and evaporated to dryness. The residue is chromatographed on silica gel using a mixture of ethyl acetate-ethanol (90:10) as the eluent to yield 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butylimino]-tetrahydro-4,4-dimethyl-6H-1,3-oxazine-6-one, m.p. 124°-6° C. when crystallized from aqueous methanol (Rf 0.3) and 1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]tetrahydro-6,6-dimethylpyrimidine-2,4-dione, as an oil (Rf 0.2).

1. filtrationfiltered
2. customevaporated to dryness
3. customThe residue is chromatographed on silica gel using
4. additiona mixture of ethyl acetate-ethanol (90:10) as the eluent