Methanesulfonic Acid → HCID 13809050, compound

HRID 2309851Notes

Reaction equation

[CH3:1][CH:2]([CH3:14])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:13])[CH2:11][CH3:12])=[CH:6][CH:5]=1.C(O)(=O)[C@@H:16]([C@H:18]([C:20]([OH:22])=[O:21])O)[OH:17].[CH:25]([O:30]C)([O:28][CH3:29])OC.[CH3:32]S(O)(=O)=O>>[CH3:32][O:22][C:20]([C@H:18]1[C@H:16]([C:25]([O:28][CH3:29])=[O:30])[O:17][C:10]([CH2:11][CH3:12])([C:7]2[CH:6]=[CH:5][C:4]([CH2:3][CH:2]([CH3:1])[CH3:14])=[CH:9][CH:8]=2)[O:13]1)=[O:21]

Participants

Reactant 4

HCID 6395Methanesulfonic Acid

HCID 9005Trimethyl orthoformate

HCID 1088341-(4-(2-Methylpropyl)phenyl)-1-propanone

HCID 444305L-Tartaric acid

Product 1

HCID 13809050HCID 13809050, compound

Conditions

Temperature: 50 °C

Procedure

A mixture of 1-[4-(2-methylpropyl)-phenyl]-propan-1-one (110 g; 0.58 moles), dimethyl ester of L(+) tartaric acid (206 g; 1.16 moles) and trimethyl orthoformate (122.7 g; 1.16 moles) is gradually heated up to complete solution (50° C. The solution is added with methanesulphonic acid (3.9 g; 0.04 moles).

Sources & evidence

ORD record: ord-2348d5bb26bc49d89ca9ba7f6fe29ec3
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04697036

Reaction notes

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