Hydrochloric Acid → 3-Methoxy-4-(7H-purin-8-yl)benzamide

HRID 2309883Notes

Reaction equation

HRID 2309883 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1.Cl.[OH-:21].[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:10])=[O:21])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 132845293-Methoxy-4-(7H-purin-8-yl)benzonitrile

Product 1

HCID 132845313-Methoxy-4-(7H-purin-8-yl)benzamide

Procedure

One gram of 8-(2'-methoxy-4'-cyano-phenyl)-purine was dissolved in 75 ml of 2N sodium hydroxide solution and refluxed for 15 minutes. Then, the mixture was acidified with hydrochloric acid, and the mixture precipitated was separated into its components by use of silica gel [eluant:methylene chloride/ethanol (7:3 to 1:1)].

Workup

  1. temperaturerefluxed for 15 minutes
  2. customthe mixture precipitated
  3. customwas separated into its components by use of silica gel [eluant:methylene chloride/ethanol (7:3 to 1:1)]

Sources & evidence

ORD record
ord-46072a7ae601409092a8ae54ad079d8c
Source dataset
uspto-grants-1987_09
Patent number
US04696931

Reaction notes

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