Hydrochloric Acid → HCID 20184577, compound

HRID 2309886Notes

Reaction equation

HRID 2309886 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[CH3:16][NH2:17].[NH2:18][C:19]1[C:24]([NH2:25])=[CH:23][N:22]=[CH:21][N:20]=1.Cl>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([NH:17][CH3:16])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:25][C:24]2[C:19](=[N:20][CH:21]=[N:22][CH:23]=2)[N:18]=1

Participants

5

Reactant 4

HCID 313Hydrochloric Acid2×HCID 6329MethylamineHCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

Product 1

HCID 20184577HCID 20184577, compound

Procedure

Prepared analogously to Example 50 from 2-methoxy-4-chlorosulfonyl-benzoic acid, aqueous methylamine solution, and 4,5-diamino-pyrimidine. The crude free base was converted into the hydrochloride with 2N hydrochloride acid, and the hydrochloride was purified by boiling with methanol.

Workup

  1. customthe hydrochloride was purified

Sources & evidence

ORD record
ord-7dccb0ae0f414ebabf152484547b1d01
Source dataset
uspto-grants-1987_09
Patent number
US04696931

Reaction notes

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