Hydrogen Bromide → HCID 178527432, compound

HRID 230989Notes

Reaction equation

HRID 230989 reaction equation
N[C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.N([O-])=O.[Na+].Br.[S:12](=[O:14])=[O:13].[ClH:15]>[Cu]>[NH:4]1[CH:5]=[CH:6][C:2]([S:12]([Cl:15])(=[O:14])=[O:13])=[N:3]1

Participants

7

Reactant 5

HCID 260Hydrogen BromideHCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 23668193Sodium NitriteHCID 178418806HCID 178418806, compound

Product 1

HCID 178527432HCID 178527432, compound

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

Namely, (1) according to Reaction scheme 4, an aminopyrazole is converted into a diazonium salt by using sodium nitrite or the like in hydrochloric acid, hydrobromic acid or the like and then sulfur dioxide is reacted with the resulting diazonium salt in the presence of a catalyst which is used usually for diazonium decomposition such as a copper salt or the like, to afford a corresponding pyrazolesulfonyl chloride. With the resulting compound was reacted an aqueous ammonia to give the desired pyrazolesulfonamide (V).

Sources & evidence

ORD record
ord-1706363585de4458bf652a1b85cc2fec
Source dataset
uspto-grants-1989_07
Patent number
US04844728

Reaction notes

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