HCID 20184509, compound → HCID 20184521, compound

HRID 2309906Notes

Reaction equation

HRID 2309906 reaction equation
[NH:1]([C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1)C(C)=O>Cl>[NH2:1][C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1

Participants

3

Reactant 1

HCID 20184509HCID 20184509, compound

Product 1

HCID 20184521HCID 20184521, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

Five grams (13.3 mmol) of 5-acetamino-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole were suspended in 150 ml of concentrated hydrochloric acid and stirred at 80° C. for two hours. After cooling, the crude product precipitated was subjected to suction filtration and chromatographed on 500 gm of aluminium oxide (neutral) (eluant: methylene chloride with 2.5% ethanol).

Workup

  1. temperatureAfter cooling
  2. customthe crude product precipitated
  3. filtrationwas subjected to suction filtration
  4. customchromatographed on 500 gm of aluminium oxide (neutral) (eluant: methylene chloride with 2.5% ethanol)

Sources & evidence

ORD record
ord-4710495d79344d1583bc71cc402bb8cd
Source dataset
uspto-grants-1987_09
Patent number
US04696931

Reaction notes

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