反应详情

A THF solution of 0.1 mole of (L)-(-)-2-pentanol and 0.1 mole of triethylamine was stirred at 0° C., and a THF solution of 0.12 mole of 4-carbobenzoxyoxybenzoyl chloride was added dropwise. The temperature was returned to the room temperature slowly, and stirring was carried out for 8 hours. After the reaction, the reaction solution was ether extracted, dried, and concentrated, then purified by column chromatography, to obtain 4.4 g of 4-carbobenzoxyoxybenzoic acid 1-methylbutyl ester. (yield: 13%)

1. customwas returned to the room temperature
2. customAfter the reaction
3. extractionextracted
4. customdried
5. concentrationconcentrated
6. custompurified by column chromatography