Hydrochloric Acid → HCID 178492595, compound

HRID 231030Notes

Reaction equation

HRID 231030 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[N:11]=[C:12]=[S:13].[N-:14]=[N+:15]=[N-:16].[Na+].O.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[N:11]1[C:12]([SH:13])=[N:16][N:15]=[N:14]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 33557Sodium AzideHCID 1424662,5-Dimethoxyphenyl isothiocyanate

Product 1

HCID 178492595HCID 178492595, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,5-Dimethoxyphenylisothiocyanate (39 g, 0.22 mol) and sodium azide (14.3 g, 0.22 mol) were added to a mixture of water (150 ml) and ethanol (60 ml) and the mixture was heated on a steam bath to about 80° C. to 90° C. with stirring for 3 hours. The reaction mixture was cooled to room temperature and a 2N HCl solution (100 ml) was added. The raw crystals formed were collected by filtration and recrystallized from isopropanol to obtain 1-(2,5-dimethoxyphenyl)-5-mercaptotetrazole (35.7 g, yield 75%). The melting point was 151° to 152° C.

Workup

  1. temperaturethe mixture was heated on a steam bath to about 80° C. to 90° C.
  2. customThe raw crystals formed
  3. filtrationwere collected by filtration
  4. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-e4af83f098bc41be8d9e0a820e79d5e8
Source dataset
uspto-grants-1989_07
Patent number
US04845020

Reaction notes

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