Tetrahydrofuran → 4-[5-(3-amino-3-methylbut-1-enyl)thiophen-2-yl]-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidin-2-amine
Reaction equation
[Al+3:30].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[H-:29].[H-:32].[H-:33].[H-:34].[Li+:31].[NH2:1][C:2]([C:3]#[C:4][c:5]1[cH:6][cH:7][c:8](-[c:10]2[n:11][c:12]([NH:16][CH:17]3[CH2:18][C:19]([CH3:25])([CH3:26])[NH:20][C:21]([CH3:23])([CH3:24])[CH2:22]3)[n:13][cH:14][cH:15]2)[s:9]1)([CH3:27])[CH3:28]>>[NH2:1][C:2]([CH:3]=[CH:4][c:5]1[cH:6][cH:7][c:8](-[c:10]2[n:11][c:12]([NH:16][CH:17]3[CH2:18][C:19]([CH3:25])([CH3:26])[NH:20][C:21]([CH3:23])([CH3:24])[CH2:22]3)[n:13][cH:14][cH:15]2)[s:9]1)([CH3:27])[CH3:28]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-0e3077ccfd4f4ecfb2584dbed32f6f40
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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