HCID 178495125, compound → HCID 178494749, compound

HRID 231142Notes

Reaction equation

HRID 231142 reaction equation
Cl[CH:2]([C:6]1[C:15]([C:16]([NH:18][C:19]2[S:20][CH:21]=[CH:22][N:23]=2)=[O:17])=[C:14]([OH:24])[C:13]2[C:8](=[CH:9][C:10]([Cl:25])=[CH:11][CH:12]=2)[N:7]=1)[CH2:3][O:4][CH3:5]>O1CCCC1>[CH3:5][O:4][CH2:3][CH:2]1[C:6]2=[N:7][C:8]3[CH:9]=[C:10]([Cl:25])[CH:11]=[CH:12][C:13]=3[C:14]([OH:24])=[C:15]2[C:16](=[N:18][C:19]2[S:20][CH:21]=[CH:22][N:23]=2)[O:17]1

Participants

3

Reactant 1

HCID 178495125HCID 178495125, compound

Product 1

HCID 178494749HCID 178494749, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Using the procedure of Step C of Example 1, the product of Step B was reacted at reflux for 24 hours in tetrahydrofuran to obtain a 65% yield of 1,3-dihydro-3-methoxymethyl-1-[(2-thiazolyl)-imino]-6-chloro-furo[3,4-b]-quinoline-9-ol melting at >270° C.

Sources & evidence

ORD record
ord-0843fcb5b477409fb438f1a6d0fb4404
Source dataset
uspto-grants-1989_07
Patent number
US04845105

Reaction notes

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