Dimethylformamide → 8-[3-(5-chloro-1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

HRID 2311474Notes

Reaction equation

HRID 2311474 reaction equation
[CH3:1][S:2]([OH:3])(=[O:4])=[O:5].[CH3:38][N:39]([CH3:40])[CH:41]=[O:42].[Cl:6][c:7]1[cH:8][c:9]2[c:10]([n:11]([CH2:15][CH2:16][CH2:17][OH:18])[c:12](=[O:14])[nH:13]2)[cH:19][cH:20]1.[c:21]1([N:27]2[CH2:28][NH:29][C:30](=[O:37])[C:31]23[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]3)[cH:22][cH:23][cH:24][cH:25][cH:26]1>>[Cl:6][c:7]1[cH:8][c:9]2[c:10]([n:11]([CH2:15][CH2:16][CH2:17][N:34]3[CH2:33][CH2:32][C:31]4([N:27]([c:21]5[cH:22][cH:23][cH:24][cH:25][cH:26]5)[CH2:28][NH:29][C:30]4=[O:37])[CH2:36][CH2:35]3)[c:12](=[O:14])[nH:13]2)[cH:19][cH:20]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6395Methanesulfonic AcidHCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 30173585-chloro-1,3-dihydro-1-(3-hydroxypropyl)-2H-benzimidazol-2-one

Product 1

HCID 203855858-[3-(5-chloro-1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Sources & evidence

ORD record
ord-31b6d0cdf6f94ba99df3f5f322800a29
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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