Propanal → 2-anilino-7-chloro-6-fluoro-5-(1-hydroxypropyl)-1-phenyl-1,8-naphthyridin-4(1H)-one
Reaction equation
[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:27][C:28]1([CH3:29])[CH2:30][CH2:31][CH2:32][C:33]([CH3:34])([CH3:35])[NH:36]1.[CH3:37][CH2:38][CH2:39][CH2:40][Li:41].[CH:42]([CH2:43][CH3:44])=[O:45].[NH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[n:9](-[c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[c:10]2[n:11][c:12]([Cl:20])[c:13]([F:19])[cH:14][c:15]2[c:16](=[O:18])[cH:17]1>>[NH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[n:9](-[c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[c:10]2[n:11][c:12]([Cl:20])[c:13]([F:19])[c:14]([CH:42]([CH2:43][CH3:44])[OH:45])[c:15]2[c:16](=[O:18])[cH:17]1Participants
6
Sources & evidence
- ORD record
- ord-1d62a970a3c64b76968181a77315d548
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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