4-Nitrophenyl chloroformate → HCID 14154330, compound

HRID 231164Notes

Reaction equation

HRID 231164 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][S:9][C:10]2[NH:14][C:13]3=[CH:15][S:16][CH:17]=[C:12]3[N:11]=2)=[N:6][CH:7]=1.Cl[C:19]([O:21][C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=1)=[O:20]>C1(C)C=CC=CC=1.C(OCC)(=O)C>[N+:28]([C:25]1[CH:24]=[CH:23][C:22]([O:21][C:19]([N:11]2[C:12]3=[CH:17][S:16][CH:15]=[C:13]3[N:14]=[C:10]2[S:9][CH2:8][C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)=[O:20])=[CH:27][CH:26]=1)([O-:30])=[O:29]

Participants

4

Reactant 2

HCID 821294-Nitrophenyl chloroformateHCID 14014797HCID 14014797, compound

Product 1

HCID 14154330HCID 14154330, compound

Reagents, catalysts & solvents 1

HCID 21584019Toluene ethylacetateSolvent

Procedure

The title compound was prepared in analogy to Example 17 from 2-(5-methyl-2-picolylmercapto)-1H-thieno[3,4-d]imidazole and p-nitrophenyl chloroformate. After working up and chromatography on silica gel using toluene/ethyl acetate (1:1), the appropriate fractions were crystallized from ethyl acetate, and the title compound was obtained. Melting point 165°-168° C.

Workup

  1. customthe appropriate fractions were crystallized from ethyl acetate

Sources & evidence

ORD record
ord-eda4355aae754c7fa6ee8def2c467481
Source dataset
uspto-grants-1989_07
Patent number
US04845118

Reaction notes

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