Hydroxide → (5-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)-1,3-dihydro-2H-isoindol-2-yl)acetic acid

HRID 2311742Notes

Reaction equation

HRID 2311742 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[Li+:36].[OH-:35].[OH2:33].[OH2:34].[c:1]1([C:7]2([c:10]3[cH:11][cH:12][c:13]4[c:14]([n:15]3)[s:16][c:17](-[c:19]3[cH:20][c:21]5[c:25]([cH:26][cH:27]3)[CH2:24][N:23]([CH2:28][C:29](=[O:30])[O:31][CH3:32])[CH2:22]5)[n:18]4)[CH2:8][CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]2([c:10]3[cH:11][cH:12][c:13]4[c:14]([n:15]3)[s:16][c:17](-[c:19]3[cH:20][c:21]5[c:25]([cH:26][cH:27]3)[CH2:24][N:23]([CH2:28][C:29](=[O:30])[OH:31])[CH2:22]5)[n:18]4)[CH2:8][CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 961HydroxideHCID 962Water2×HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 67111938Methyl 2-(5-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)isoindolin-2-yl)acetate

Product 1

HCID 59174887(5-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)-1,3-dihydro-2H-isoindol-2-yl)acetic acid

Sources & evidence

ORD record
ord-11b7c8c2deed449db62e2314dd7bc490
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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