Diethyl Oxalate → Ethyl 4-fluoro-2-methyl-α-oxobenzeneacetate

HRID 2311924Notes

Reaction equation

HRID 2311924 reaction equation
[Br:6][c:7]1[c:8]([CH3:14])[cH:9][c:10]([F:13])[cH:11][cH:12]1.[C:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])(=[O:21])[O:22][CH2:23][CH3:24].[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1>>[c:7]1([C:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])=[O:21])[c:8]([CH3:14])[cH:9][c:10]([F:13])[cH:11][cH:12]1

Participants

5

Reactant 4

HCID 7268Diethyl OxalateHCID 8028TetrahydrofuranHCID 967432-Bromo-5-fluorotolueneHCID 178418339Butyllithium

Product 1

HCID 24722272Ethyl 4-fluoro-2-methyl-α-oxobenzeneacetate

Sources & evidence

ORD record
ord-49df80d8b0cb47faa98cef0d443c8499
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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