Acetate → 6,7-Dimethoxy-3',4'-dihydro-1'H-[1,2']biisoquinolinyl

HRID 2312176Notes

Reaction equation

HRID 2312176 reaction equation
[C:50]([O-:51])(=[O:52])[CH3:53].[C:55]([O-:56])(=[O:57])[CH3:58].[CH2:16]1[NH:17][CH2:18][CH2:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21.[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:26][C:27]([CH3:28])([O-:29])[CH3:30].[CH3:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[CH3:44][CH2:45][O:46][C:47]([CH3:48])=[O:49].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]2[cH:7][c:8]([O:14][CH3:15])[c:9]([O:12][CH3:13])[cH:10][c:11]12.[K+:31].[Pd+2:54]>>[c:2]1([N:17]2[CH2:16][c:25]3[c:20]([cH:21][cH:22][cH:23][cH:24]3)[CH2:19][CH2:18]2)[n:3][cH:4][cH:5][c:6]2[cH:7][c:8]([O:14][CH3:15])[c:9]([O:12][CH3:13])[cH:10][c:11]12

Participants

10

Reactant 9

HCID 175Acetate2×HCID 813Potassium CationHCID 1140TolueneHCID 70461,2,3,4-TetrahydroisoquinolineHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 45749132-Methylpropan-2-olateHCID 106407081-Chloro-6,7-dimethoxyisoquinoline

Product 1

HCID 116454496,7-Dimethoxy-3',4'-dihydro-1'H-[1,2']biisoquinolinyl

Sources & evidence

ORD record
ord-36dcc9090eaf499dbceb158fedba3182
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…