Hydrochloric Acid → 6-(1-Acetylpiperidin-3-yloxy)-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline
Reaction equation
[CH2:46]([Cl:47])[Cl:48].[CH3:1][C:2](=[O:3])[O:4][C:5](=[O:6])[CH3:7].[CH:37]([N:38]([CH:39]([CH3:40])[CH3:41])[CH2:42][CH3:43])([CH3:44])[CH3:45].[Cl:9][c:10]1[c:11]([F:36])[c:12]([NH:13][c:14]2[n:15][cH:16][n:17][c:18]3[cH:19][c:20]([O:31][CH3:32])[c:21]([O:24][CH:25]4[CH2:26][NH:27][CH2:28][CH2:29][CH2:30]4)[cH:22][c:23]23)[cH:33][cH:34][cH:35]1.[ClH:8]>>[CH3:1][C:2](=[O:3])[N:27]1[CH2:26][CH:25]([O:24][c:21]2[c:20]([O:31][CH3:32])[cH:19][c:18]3[n:17][cH:16][n:15][c:14]([NH:13][c:12]4[c:11]([F:36])[c:10]([Cl:9])[cH:35][cH:34][cH:33]4)[c:23]3[cH:22]2)[CH2:30][CH2:29][CH2:28]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-5043f297812a4db89fa5467ba61560ca
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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