Acetone → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(2-methylthioethoxy)quinazoline
Reaction equation
[CH3:34][C:35](=[O:36])[CH3:37].[CH:30]([OH:31])([CH3:32])[CH3:33].[Cl:2][c:3]1[n:4][cH:5][n:6][c:7]2[cH:8][c:9]([O:15][CH2:16][CH2:17][S:18][CH3:19])[c:10]([O:13][CH3:14])[cH:11][c:12]12.[ClH:1].[F:20][c:21]1[c:22]([NH2:23])[cH:24][c:25]([OH:29])[c:26]([CH3:28])[cH:27]1>>[c:3]1([NH:23][c:22]2[c:21]([F:20])[cH:27][c:26]([CH3:28])[c:25]([OH:29])[cH:24]2)[n:4][cH:5][n:6][c:7]2[cH:8][c:9]([O:15][CH2:16][CH2:17][S:18][CH3:19])[c:10]([O:13][CH3:14])[cH:11][c:12]12Participants
6
Sources & evidence
- ORD record
- ord-492f08ed68c34741ace1ff332ef05c2e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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