反应详情

To a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer, reflux condenser and addition funnel was added (1,1-dimethylethoxy)acetic acid (24.00 g, 0.182 moles) and 300 ml of toluene under nitrogen. Oxalyl chloride (46.10 g, 0.363 moles) was then added dropwise and to this mixture was added N,N-dimethylformamide (0.25 g, 0.003 moles). This solution was heated at 30°-40° C. for 5 hours and then concentrated in vacuo to give 14.5 g of the product as a brown oil.

1. customTo a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer
2. temperaturereflux
3. additioncondenser and addition funnel
4. temperatureThis solution was heated at 30°-40° C. for 5 hours
5. concentrationconcentrated in vacuo