Phosphorus oxychloride → N-(4,6-Dichloropyrido[3,2-d]pyrimidin-2-yl)acetamide

HRID 2314302Notes

Reaction equation

HRID 2314302 reaction equation
[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[nH:6][c:7](=[O:16])[c:8]2[c:9]([n:10]1)[cH:11][cH:12][c:13]([Cl:15])[n:14]2.[CH:17]([N:18]([CH2:19][CH3:20])[CH:21]([CH3:22])[CH3:23])([CH3:24])[CH3:25].[O:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1.[P:26]([Cl:27])([Cl:28])([Cl:29])=[O:30]>>[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[n:6][c:7]([Cl:28])[c:8]2[c:9]([n:10]1)[cH:11][cH:12][c:13]([Cl:15])[n:14]2

Participants

5

Reactant 4

HCID 24813Phosphorus oxychlorideHCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 135978119N-(6-Chloro-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-2-yl)acetamide

Product 1

HCID 57698319N-(4,6-Dichloropyrido[3,2-d]pyrimidin-2-yl)acetamide

Sources & evidence

ORD record
ord-b10558e159b243908a47489acedab856
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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