Sodium ion → N-(4-isopropoxyphenyl)-2-(1-benzyl-4-hydroxypiperidin-4-yl)acetamide

HRID 2314399Notes

Reaction equation

HRID 2314399 reaction equation
[CH2:32]([Li:33])[CH2:34][CH2:35][CH3:36].[CH2:37]([c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[N:44]1[CH2:45][CH2:46][C:47](=[O:50])[CH2:48][CH2:49]1.[CH:17]([N-:18][CH:19]([CH3:20])[CH3:21])([CH3:22])[CH3:23].[CH:25]([NH:26][CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[CH:3]([CH3:4])([CH3:5])[O:6][c:7]1[cH:8][cH:9][c:10]([NH:11][C:12]([CH3:13])=[O:14])[cH:15][cH:16]1.[H-:1].[Li+:24].[Na+:2].[O:51]1[CH2:52][CH2:53][CH2:54][CH2:55]1>>[CH:3]([CH3:4])([CH3:5])[O:6][c:7]1[cH:8][cH:9][c:10]([NH:11][C:12]([CH2:13][C:47]2([OH:50])[CH2:46][CH2:45][N:44]([CH2:37][c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[CH2:49][CH2:48]2)=[O:14])[cH:15][cH:16]1

Participants

10

Reactant 9

HCID 923Sodium ionHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 192201-Benzyl-4-piperidoneHCID 28486Lithium ionHCID 952134'-IsopropoxyacetanilideHCID 166653HydrideHCID 5062348DiisopropylamideHCID 178418339Butyllithium

Product 1

HCID 18002919N-(4-isopropoxyphenyl)-2-(1-benzyl-4-hydroxypiperidin-4-yl)acetamide

Sources & evidence

ORD record
ord-198eefc6c63d42d49f1215e4ac8fb9f2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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