Water → 3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)benzenamine

HRID 2314403Notes

Reaction equation

HRID 2314403 reaction equation
[Al+3:2].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[NH2:7][c:8]1[cH:9][c:10]([C:18]2=[CH:19][CH2:20][N:21]([C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:22][CH2:23]2)[cH:11][c:12]([C:14]([F:15])([F:16])[F:17])[cH:13]1.[OH2:31]>>[NH2:7][c:8]1[cH:9][c:10]([C:18]2=[CH:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]2)[cH:11][c:12]([C:14]([F:15])([F:16])[F:17])[cH:13]1

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 67520234tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 219596433-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)benzenamine

Sources & evidence

ORD record
ord-db3c85abc90d4e80984bb546cb1820b1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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