Water → 8-(p-Pentylcinnamoyl)amino-1,4-benzodioxane-2-acetonitrile

HRID 231564Notes

Reaction equation

HRID 231564 reaction equation
FC(F)(F)C(OC(=O)C(F)(F)F)=O.[CH2:14]([C:19]1[CH:43]=[CH:42][C:22]([CH:23]=[CH:24][C:25]([NH:27][C:28]2[C:33]3[O:34][CH:35]([CH2:38][C:39]([NH2:41])=O)[CH2:36][O:37][C:32]=3[CH:31]=[CH:30][CH:29]=2)=[O:26])=[CH:21][CH:20]=1)[CH2:15][CH2:16][CH2:17][CH3:18].N1C=CC=CC=1.O>C1COCC1>[CH2:14]([C:19]1[CH:20]=[CH:21][C:22]([CH:23]=[CH:24][C:25]([NH:27][C:28]2[C:33]3[O:34][CH:35]([CH2:38][C:39]#[N:41])[CH2:36][O:37][C:32]=3[CH:31]=[CH:30][CH:29]=2)=[O:26])=[CH:42][CH:43]=1)[CH2:15][CH2:16][CH2:17][CH3:18]

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 9845Trifluoroacetic anhydrideHCID 542031508-(p-Pentylcinnamoyl)amino-1,4-benzodioxane-2-acetamide

Product 1

HCID 545344778-(p-Pentylcinnamoyl)amino-1,4-benzodioxane-2-acetonitrile

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Trifluoroacetic anhydride (0.1 m) was added to a solution of 8-(p-pentylcinnamoyl)amino-1,4-benzodioxane-2-acetamide (191 mg; synthesized in reference example 4) in THF (10 ml) cooling with ice. And pyridine (0.02 ml) was added to the mixture. After stirring for 10 min, the mixture was poured into water. The mixture was extracted with ethyl acetate. The extract was dried, concentrated under reduced pressure to give the title compound.

Workup

  1. temperaturecooling with ice
  2. extractionThe mixture was extracted with ethyl acetate
  3. customThe extract was dried
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3905e3a0cd8e42cb9715ebae1e6d24d1
Source dataset
uspto-grants-1989_07
Patent number
US04847275

Reaction notes

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