Potassium Cation → 1-(4-Amino-3-fluoro-phenyl)-piperidin-2-one

HRID 2315946Notes

Reaction equation

HRID 2315946 reaction equation
[C:10]1(=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][NH:15]1.[CH2:41]1[O:42][CH2:43][CH2:44][O:45][CH2:46]1.[CH3:33][CH2:34][O:35][C:36]([CH3:37])=[O:38].[Cu:39][I:40].[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([I:9])[cH:8]1.[K+:22].[K+:23].[K+:24].[NH2:25][CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][CH:31]1[NH2:32].[P:17]([O-:18])([O-:19])([O-:20])=[O:21]>>[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([N:15]2[C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14]2)[cH:8]1

Participants

9

Reactant 8

HCID 813Potassium Cation3×HCID 1061PhosphateHCID 46101,2-DiaminocyclohexaneHCID 8857Ethyl AcetateHCID 126652-PiperidoneHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 1856942-Fluoro-4-iodoaniline

Product 1

HCID 117890101-(4-Amino-3-fluoro-phenyl)-piperidin-2-one

Sources & evidence

ORD record
ord-fa82c6174f384c3ab1d1bb703e05f7c7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…