Oxalyl chloride → 5-Nitro-3-chloro-2,4-difluorobenzoyl chloride

HRID 23166Notes

Reaction equation

HRID 23166 reaction equation
[N+:1]([C:4]1[C:5]([F:15])=[C:6]([Cl:14])[C:7]([F:13])=[C:8]([CH:12]=1)[C:9](O)=[O:10])([O-:3])=[O:2].C(Cl)(=O)C([Cl:19])=O>ClCCl.CN(C=O)C>[N+:1]([C:4]1[C:5]([F:15])=[C:6]([Cl:14])[C:7]([F:13])=[C:8]([CH:12]=1)[C:9]([Cl:19])=[O:10])([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 155499183-Chloro-2,4-difluoro-5-nitrobenzoic acid

Product 1

HCID 155499195-Nitro-3-chloro-2,4-difluorobenzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

An amount of 3.47 g (0.015 mole) of 5-nitro-3-chloro-2,4-difluorobenzoic acid and 2.03 g (0.016 mole) of oxalyl chloride are dissolved in 15 ml of dichloromethane then two drops of DMF are added. The reaction is stirred for 14 hours then the solvent is evaporated under vacuum to afford the desired product.

Workup

  1. customthe solvent is evaporated under vacuum

Sources & evidence

ORD record
ord-bc89b3c8c1c4439892dd33fbdfc6e764
Source dataset
uspto-grants-2005_02
Patent number
US06849740B2

Reaction notes

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