Imidazole → HCID 10058334, compound

HRID 231791Notes

Reaction equation

HRID 231791 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([CH3:10])[N:3]=1.[NH:11]1[CH:15]=[CH:14][N:13]=[CH:12]1>O1CCCC1>[N:11]1([C:2]2[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([CH3:10])[N:3]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 124905712-Chloro-4-methoxy-6-methylpyrimidine

Product 1

HCID 10058334HCID 10058334, compoundYield 51.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In anhydrous tetrahydrofuran, 159 mg of 2-chloro-4-methoxy-6-methylpyrimidine was substituted with 68 mg of imidazole. The reaction mixture was treated according to the Procedure of Example 5 to yield 97 mg of 2-(1-imidazolyl)-4-methoxy-6-methylpyrimidine, recrystallized from n-hexane, having a melting point of 53°-54° C.

Workup

  1. additionThe reaction mixture was treated

Sources & evidence

ORD record
ord-ab19f8767a0c4551ae71325587412845
Source dataset
uspto-grants-1989_07
Patent number
US04849424

Reaction notes

Loading…