1H-1,2,4-Triazole → HCID 10679259, compound

HRID 231792Notes

Reaction equation

HRID 231792 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([CH3:10])[N:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1>O1CCCC1>[CH3:9][O:8][C:6]1[CH:5]=[C:4]([CH3:10])[N:3]=[C:2]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)[N:7]=1

Participants

4

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 124905712-Chloro-4-methoxy-6-methylpyrimidine

Product 1

HCID 10679259HCID 10679259, compoundYield 48.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In anhydrous tetrahydrofuran, 159 mg of 2-chloro-4-methoxy-6-methylpyrimidine was substituted with 69 mg of 1,2,4-triazole. The reaction mixture was treated according to the procedure as in Example 5 to yield 92 mg of 4-methoxy-6-methyl-2-(1,2,4-triazol-1-yl)-pyrimidine, recrystallized from n-hexane, having a melting point of 142.5°-143° C.

Workup

  1. additionThe reaction mixture was treated

Sources & evidence

ORD record
ord-ea28cb82fec64b66bd289f086b02e378
Source dataset
uspto-grants-1989_07
Patent number
US04849424

Reaction notes

Loading…