Methanol → HCID 10725947, compound

HRID 231802Notes

Reaction equation

HRID 231802 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)[N:3]=1.[Na].[CH3:14][OH:15]>>[N:8]1([C:4]2[N:3]=[C:2]([O:15][CH3:14])[CH:7]=[CH:6][N:5]=2)[CH:12]=[CH:11][N:10]=[CH:9]1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 106074834-chloro-2-(1H-imidazol-1-yl)pyrimidine

Product 1

HCID 10725947HCID 10725947, compound

Procedure

Following the procedure of Example 15, 180 mg of 4-chloro-2-(1-imidazolyl)pyrimidine were reacted with 23 mg of sodium metal and 2 ml of anhydrous methanol was carried out to yield 134 mg of 2-(1-imidazolyl)-4-methoxypyrimidine, having a melting point of 78°-79° C., recrystallized from a mixture of n-hexane and ethyl acetate.

Sources & evidence

ORD record
ord-eb5c83754db84ac184d5b230752f497a
Source dataset
uspto-grants-1989_07
Patent number
US04849424

Reaction notes

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