Tetrahydrofuran → 5-{3-[2-[4-(3-Cyclohexyl-propenyl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide

HRID 2318369Notes

Reaction equation

HRID 2318369 reaction equation
[BH:19]([OH:20])[OH:21].[Br:22][c:23]1[cH:24][cH:25][c:26]([CH2:27][c:28]2[n:29](-[c:41]3[cH:42][c:43]([N:47]4[CH2:48][C:49](=[O:54])[NH:50][S:51]4(=[O:52])=[O:53])[cH:44][cH:45][cH:46]3)[cH:30][c:31](-[c:33]3[c:34]([Cl:40])[cH:35][c:36]([Cl:39])[cH:37][cH:38]3)[n:32]2)[cH:55][cH:56]1.[CH2:57]1[O:58][CH2:59][CH2:60][CH2:61]1.[CH:10]12[CH2:11][CH2:12][CH2:13][CH:14]([BH:15]1)[CH2:16][CH2:17][CH2:18]2.[CH:1]1([CH2:7][C:8]#[CH:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1>>[CH:1]1([CH2:7][CH:8]=[CH:9][c:23]2[cH:24][cH:25][c:26]([CH2:27][c:28]3[n:29](-[c:41]4[cH:42][c:43]([N:47]5[CH2:48][C:49](=[O:54])[NH:50][S:51]5(=[O:52])=[O:53])[cH:44][cH:45][cH:46]4)[cH:30][c:31](-[c:33]4[c:34]([Cl:40])[cH:35][c:36]([Cl:39])[cH:37][cH:38]4)[n:32]3)[cH:55][cH:56]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 61668Boronic AcidHCID 789669-Borabicyclo(3.3.1)nonaneHCID 87265(Prop-2-yn-1-yl)cyclohexaneHCID 593055095-{3-[2-(4-Bromo-benzyl)-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide

Product 1

HCID 685855345-{3-[2-[4-(3-Cyclohexyl-propenyl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,2,5-thiadiazolidine-3-one-1,1-dioxide

Sources & evidence

ORD record
ord-4a2aa0b218334837acc509ee750191d3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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