Tetrahydrofuran → 2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane

HRID 2318443Notes

Reaction equation

HRID 2318443 reaction equation
[CH2:41]([O:42][C:43]([N:44]=[N:45][C:46]([O:47][CH2:48][CH3:49])=[O:50])=[O:51])[CH3:52].[O:53]1[CH2:54][CH2:55][CH2:56][CH2:57]1.[OH:1][C:2]([CH2:3][OH:4])([CH2:5][C:6]([CH3:7])([CH3:8])[c:9]1[c:10]([O:16][CH3:17])[cH:11][cH:12][c:13]([F:15])[cH:14]1)[C:18]([F:19])([F:20])[F:21].[c:22]1([P:23]([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:36][cH:37][cH:38][cH:39][cH:40]1>>[C:2]1([CH2:5][C:6]([CH3:7])([CH3:8])[c:9]2[c:10]([O:16][CH3:17])[cH:11][cH:12][c:13]([F:15])[cH:14]2)([C:18]([F:19])([F:20])[F:21])[CH2:3][O:4]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 219489282-Hydroxy-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethyl-pentanol

Product 1

HCID 160992392-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane

Sources & evidence

ORD record
ord-4034fb4be4704cc4b098f188e62e093b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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