Fumaric Acid → 116870-77-0

HRID 231855Notes

Reaction equation

HRID 231855 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10](=[O:17])[N:9]1[CH2:18][CH2:19][NH:20][CH:21]([CH3:23])[CH3:22].[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]/[C:27]([OH:29])=[O:28]>O1CCCC1>[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]/[C:27]([OH:29])=[O:28].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10](=[O:17])[N:9]1[CH2:18][CH2:19][NH:20][CH:21]([CH3:23])[CH3:22]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 3088035HCID 3088035, compound

Product 1

HCID 6450690116870-77-0Yield 84.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To 100 ml of a tetrahydrofuran solution of 7.62 g of the resulting Compound 6 was added 100 ml of a tetrahydrofuran solution of 2.86 g of fumaric acid. The mixture was stirred under ice cooling. Separation of the precipitated crystals by filtration gave 8.85 g of 3-(2-aminophenyl)-2-(2-isopropylaminoethyl)isoindolin-1-one monofumarate (Compound 6').

Workup

  1. customSeparation of the precipitated crystals
  2. filtrationby filtration

Sources & evidence

ORD record
ord-7e9f4462f48241388e6f3205464d4afe
Source dataset
uspto-grants-1989_07
Patent number
US04849441

Reaction notes

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