Hydrochloric Acid → 4-(4-Trifluoromethylphenyl)pyridine

HRID 2319777Notes

Reaction equation

HRID 2319777 reaction equation
[Br:2][c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1.[C:9](=[O:10])([O-:11])[O-:12].[CH3:105][O:106][CH2:107][CH2:108][O:109][CH3:110].[ClH:1].[F:15][C:16]([c:17]1[cH:18][cH:19][c:20]([B:23]([OH:24])[OH:25])[cH:21][cH:22]1)([F:26])[F:27].[Na+:13].[Na+:14].[Pd:28].[c:29]1([P:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1.[c:48]1([P:49]([c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[cH:62][cH:63][cH:64][cH:65][cH:66]1.[c:67]1([P:68]([c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)[c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[cH:81][cH:82][cH:83][cH:84][cH:85]1.[c:86]1([P:87]([c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[cH:100][cH:101][cH:102][cH:103][cH:104]1>>[c:3]1(-[c:20]2[cH:19][cH:18][c:17]([C:16]([F:15])([F:26])[F:27])[cH:22][cH:21]2)[cH:4][cH:5][n:6][cH:7][cH:8]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 923Sodium ion2×HCID 80711,2-DimethoxyethaneHCID 11776Triphenylphosphine4×HCID 142684-BromopyridineHCID 19660Carbonate IonHCID 23938PalladiumHCID 27343894-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 6139654-(4-Trifluoromethylphenyl)pyridine

Sources & evidence

ORD record
ord-6d5e3c4881df4ee3ba087be967ae4d8d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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