Toluene → 4,6-Dichloropyrido[3,2-d]pyrimidine

HRID 2320040Notes

Reaction equation

HRID 2320040 reaction equation
[CH3:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[CH:13]([N:14]([CH2:15][CH3:16])[CH:17]([CH3:18])[CH3:19])([CH3:20])[CH3:21].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6][cH:7][nH:8][c:9](=[O:12])[c:10]2[n:11]1.[P:22]([Cl:23])([Cl:24])([Cl:25])=[O:26]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6][cH:7][n:8][c:9]([Cl:24])[c:10]2[n:11]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 1354270966-Chloropyrido[3,2-d]pyrimidin-4(3H)-one

Product 1

HCID 105841654,6-Dichloropyrido[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-2253e33f2c764d919001b68d2c71a67c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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