Chloride → tert-butyl 4-pyridin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylate

HRID 2320053Notes

Reaction equation

HRID 2320053 reaction equation
[C:24](=[O:25])([O-:26])[O-:27].[CH3:123][O:124][CH2:125][CH2:126][O:127][CH3:128].[CH3:30][C:31]1([CH3:32])[C:33]([CH3:34])([CH3:35])[O:36][B:37]([c:38]2[cH:39][cH:40][n:41][cH:42][cH:43]2)[O:44]1.[Cl-:23].[F:1][C:2]([F:3])([F:4])[S:5]([O:6][C:7]1=[CH:12][CH2:11][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:9][CH2:8]1)(=[O:20])=[O:21].[K+:28].[K+:29].[Li+:22].[OH2:122].[cH:45]1[cH:46][cH:47][c:48]([P:49]([Pd:50]([P:51]([c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)([P:70]([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)([c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[P:89]([c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)([c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)([c:108]2[cH:109][cH:110][cH:111][cH:112][cH:113]2)[c:114]2[cH:115][cH:116][cH:117][cH:118][cH:119]2)[cH:120][cH:121]1>>[C:7]1([c:38]2[cH:39][cH:40][n:41][cH:42][cH:43]2)=[CH:12][CH2:11][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:9][CH2:8]1

Participants

10

Reactant 9

HCID 312ChlorideHCID 813Potassium Cation2×HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 19660Carbonate IonHCID 28486Lithium ionHCID 27346484-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 10991161Tert-butyl 4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine-1-carboxylateHCID 178420554HCID 178420554, compound

Product 1

HCID 67191026tert-butyl 4-pyridin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylate

Sources & evidence

ORD record
ord-bde840bab28c4ec1988df37e8550b344
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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