Isopropanol → 5-chloro-N4-(2-(difluoromethylsulfonyl)phenyl)-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)pyrimidine-2,4-diamine
Reaction equation
[CH3:40][c:41]1[cH:42][cH:43][c:44]([S:45](=[O:46])(=[O:47])[OH:48])[cH:49][cH:50]1.[CH:22]([CH3:23])([CH3:24])[O:25][c:26]1[c:27]([NH2:28])[cH:29][c:30]([CH3:39])[c:31]([CH:33]2[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]2)[cH:32]1.[CH:51]([OH:52])([CH3:53])[CH3:54].[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:21])[c:6]([NH:8][c:9]2[c:10]([S:15](=[O:16])(=[O:17])[CH:18]([F:19])[F:20])[cH:11][cH:12][cH:13][cH:14]2)[n:7]1>>[c:2]1([NH:28][c:27]2[c:26]([O:25][CH:22]([CH3:23])[CH3:24])[cH:32][c:31]([CH:33]3[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]3)[c:30]([CH3:39])[cH:29]2)[n:3][cH:4][c:5]([Cl:21])[c:6]([NH:8][c:9]2[c:10]([S:15](=[O:16])(=[O:17])[CH:18]([F:19])[F:20])[cH:11][cH:12][cH:13][cH:14]2)[n:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-9f47c418e26f4a98bef26bf0ae34ccbf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
Loading…