反应详情

温度

70 °C

In a mixture of 100 ml of ethanol and 40 ml of water were dissolved 8.0 g (200 mmol) of sodium hydroxide and 11.72 g (100 mmol) of L-norvaline. To the solution was added 27.41 g of 1-bromoethane, and the mixture was heated up to 70° C., followed by vigorously stirring for 5 hours. Thereafter, 4.0 g of sodium hydroxide was added thereto, and the stirring was continued for an additional time of 5 hours under the same condition. After the reaction, the reaction mixture was cooled, adjusted to a pH of 7 with sulfuric acid, and diluted with 1.5 liter of water to obtain N,N-di-n-butyl-L-norvaline as a fatty and oily product.

1. customwas continued for an additional time of 5 hours under the same condition
2. customAfter the reaction
3. temperaturethe reaction mixture was cooled