Hydrochloric Acid → HCID 20030629, compound

HRID 232030Notes

Reaction equation

HRID 232030 reaction equation
Cl.[NH:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:6][CH:5]=1)N.Cl.[C:18]1([CH2:24][C:25](=O)[CH3:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[CH3:26][C:25]1[NH:2][C:4]2[C:9]([C:24]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:8][C:7]([C:10]1[CH2:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=1)=[CH:6][CH:5]=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7678PhenylacetoneHCID 19780113HCID 19780113, compound

Product 1

HCID 20030629HCID 20030629, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.8 g. (20 mmole) 6-(4-hydrazinophenyl)-2,3,4,5-tetrahydropyridazin-3-one hydrochloride (according to Example 2 (a)) are suspended in 75 ml. 2N hydrochloric acid and 75 ml. ethanol, mixed with 2.8 g. (21 mmole) phenylacetone, stirred for 3 hours at 25° C., filtered off with the suction and the title compound obtained is recrystallised from methanol. Yield 4.85 g. (80% of theory); m.p. 297°-299° C.

Workup

  1. filtrationfiltered off with the suction

Sources & evidence

ORD record
ord-7d317507304d4c5fb086e4ced882c8c8
Source dataset
uspto-grants-1989_07
Patent number
US04851406

Reaction notes

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