反应详情

To a solution of 499 mg (7.33 mmol) of imidazole and 2.0 g (7.33 mmol) of 2,5-dimethoxy-3,4,6-trimethylbenzyl bromide in 12 ml of dimethylformamide, 1.2 ml of triethylamine was added and stirred at room temperature for 1 hour. The reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed with water and dried, from which the solvent was evaporated off. The residue was purified with silica gel column chromatography (chloroform-methanol(1:1)) and recrystallized from isopropyl ether, to give 0.9 g (47.3%) of 1-(2,5-dimethoxy-3,4,6-trimethylbenzyl)imidazole, m.p. 82°-83° C.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried, from which the solvent
4. customwas evaporated off
5. customThe residue was purified with silica gel column chromatography (chloroform-methanol(1:1))
6. customrecrystallized from isopropyl ether