Water → 2-chloro-4-(3-chlorophenyl)-alpha-(4-fluorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol
Reaction equation
[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[CH3:12][n:13]1[cH:14][cH:15][n:16][cH:17]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[CH3:58][CH2:59][O:60][C:61]([CH3:62])=[O:63].[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[Cl:18][Si:19]([CH2:20][CH3:21])([CH2:22][CH3:23])[CH2:24][CH3:25].[Cl:26][c:27]1[n:28][c:29]2[cH:30][cH:31][c:32]([C:44](=[O:45])[c:46]3[cH:47][cH:48][c:49]([F:52])[cH:50][cH:51]3)[cH:33][c:34]2[c:35](-[c:37]2[cH:38][c:39]([Cl:43])[cH:40][cH:41][cH:42]2)[n:36]1.[OH2:64]>>[CH3:12][n:13]1[c:14]([C:44]([c:32]2[cH:31][cH:30][c:29]3[n:28][c:27]([Cl:26])[n:36][c:35](-[c:37]4[cH:38][c:39]([Cl:43])[cH:40][cH:41][cH:42]4)[c:34]3[cH:33]2)([OH:45])[c:46]2[cH:47][cH:48][c:49]([F:52])[cH:50][cH:51]2)[cH:15][n:16][cH:17]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-db883b7828e24afca1ad36a4bebc9d20
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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