Potassium Cation → tert-butyl 4-(3-bromophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

HRID 2321385Notes

Reaction equation

HRID 2321385 reaction equation
[Br:23][c:24]1[cH:25][c:26]([I:30])[cH:27][cH:28][cH:29]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([B:14]2[O:15][C:16]([CH3:17])([CH3:18])[C:19]([CH3:20])([CH3:21])[O:22]2)=[CH:12][CH2:13]1.[CH3:37][N:38]([CH3:39])[CH:40]=[O:41].[K+:31].[K+:32].[O-:33][C:34]([O-:35])=[O:36].[Pd:42]([Cl:43])[Cl:44].[c:45]1([P:46]([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[cH:59][cH:60][cH:61][cH:62][cH:63]1.[c:64]1([P:65]([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[cH:78][cH:79][cH:80][cH:81][cH:82]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:26]2[cH:25][c:24]([Br:23])[cH:29][cH:28][cH:27]2)=[CH:12][CH2:13]1

Participants

8

Reactant 7

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 11561Benzene, 1-bromo-3-iodo-HCID 11776Triphenylphosphine2×HCID 19660Carbonate IonHCID 24290Palladium ChlorideHCID 4642098Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate

Product 1

HCID 66836951tert-butyl 4-(3-bromophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Sources & evidence

ORD record
ord-fe412600cf0e42cdb790bae729b1a4e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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