HCID 54559713, compound → HCID 14576184, compound

HRID 232144Notes

Reaction equation

HRID 232144 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][CH2:5][CH2:6][CH:7]=[CH:8][C:9]1[C:13]2[CH2:14][CH2:15][CH2:16][C:12]=2[N:11]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[N:10]=1>C(OCC)(=O)C.[Pt]=O>[CH3:1][O:2][C:3](=[O:24])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[C:13]2[CH2:14][CH2:15][CH2:16][C:12]=2[N:11]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[N:10]=1

Participants

4

Reactant 1

HCID 54559713HCID 54559713, compound

Product 1

HCID 14576184HCID 14576184, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of the compound of Example 29 (0.90 g, 2.7 mmol) in ethyl acetate (100 ml) was treated with platinum oxide (0.4 g) and reduced for 3 hours at atmospheric pressure. The catalyst was filtered, the filtrate evaporated and the residue (0.87 g) was crystallized from hexane to yield the title compound, m.p. 39°-40° C.

Workup

  1. filtrationThe catalyst was filtered
  2. customthe filtrate evaporated
  3. customthe residue (0.87 g) was crystallized from hexane

Sources & evidence

ORD record
ord-f691e64905ab4a76be3dfd9c634c9884
Source dataset
uspto-grants-1989_07
Patent number
US04851425

Reaction notes

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