Hydrochloric Acid → Ethyl 1-cyclopropyl-7,9-difluoro-8-(4-furfurylpiperazin-1-yl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylate

HRID 2321749Notes

Reaction equation

HRID 2321749 reaction equation
[CH2:28]([c:29]1[cH:30][cH:31][cH:32][o:33]1)[N:34]1[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]1.[CH3:40][S:41](=[O:42])[CH3:43].[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[CH:1]1([n:4]2[cH:5][c:6]([C:22](=[O:23])[O:24][CH2:25][CH3:26])[c:7](=[O:21])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[c:14]([F:20])[c:15]([F:19])[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1.[ClH:27]>>[CH:1]1([n:4]2[cH:5][c:6]([C:22](=[O:23])[O:24][CH2:25][CH3:26])[c:7](=[O:21])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[c:14]([F:20])[c:15]([N:37]2[CH2:36][CH2:35][N:34]([CH2:28][c:29]3[cH:30][cH:31][cH:32][o:33]3)[CH2:39][CH2:38]2)[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 7647161-(2-Furylmethyl)piperazineHCID 185491641-Cyclopropyl-3-ethoxycarbonyl-7,8,9-trifluoro-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

Product 1

HCID 18549171Ethyl 1-cyclopropyl-7,9-difluoro-8-(4-furfurylpiperazin-1-yl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylate

Sources & evidence

ORD record
ord-25af1bb332f041d48f8a9051efca6420
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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