Hydroxide → 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

HRID 2322283Notes

Reaction equation

HRID 2322283 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:19](=[O:20])[OH:21])[c:10]2[cH:11][cH:12][c:13]([OH:18])[cH:14][c:15]2[CH2:16][CH2:17]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[Li+:23].[OH-:22].[OH2:24]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:19](=[O:20])[O:21][CH3:25])[c:10]2[cH:11][cH:12][c:13]([OH:18])[cH:14][c:15]2[CH2:16][CH2:17]1

Participants

6

Reactant 5

HCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 222586022-(tert-Butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Product 1

HCID 228884912-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate

Sources & evidence

ORD record
ord-ad4fae52edbe4761bf38db6744473d7f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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