Thionyl Chloride → HCID 20031314, compound

HRID 232287Notes

Reaction equation

HRID 232287 reaction equation
S(Cl)([Cl:3])=O.[CH2:5]([O:7][CH2:8][CH:9](O)[CH2:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:13][CH2:12]1)[CH3:6].C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[Cl:3][CH:9]([CH2:8][O:7][CH2:5][CH3:6])[CH2:10][N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 20031327HCID 20031327, compound

Product 1

HCID 20031314HCID 20031314, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 100 mL of chloroform is added 24 g (0.2 mol) of thionyl chloride and 27.2 g (0.1 mol) of 1-ethoxy-3-(4-hexylpiperazin-1-yl)-2-propanol. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add saturated aqueous sodium bicarbonate until gas evolution ceases. Dry the organic phase over Na2SO4. Filter the drying agent and evaporate the solvent in vacuo to obtain the title compound.

Workup

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. dry with materialDry the organic phase over Na2SO4
  4. filtrationFilter the drying agent
  5. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-fe5e01521abc4e2e84cd520599301c70
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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