Trifluoroacetic acid → Diethyl(4-{[4-({7-[-3,4-dihydroxycyclopentyl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate
Reaction equation
[CH3:56][CH2:57][O:58][C:59]([CH3:60])=[O:61].[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH3:29])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36].[NH2:37][c:38]1[cH:39][cH:40][c:41]([CH:49]2[CH2:50][CH:51]([OH:55])[CH:52]([OH:54])[CH2:53]2)[c:42]2[c:46]1[C:45](=[O:47])[N:44]([CH3:48])[CH2:43]2>>[c:2]1([NH:37][c:38]2[cH:39][cH:40][c:41]([CH:49]3[CH2:50][CH:51]([OH:55])[CH:52]([OH:54])[CH2:53]3)[c:42]3[c:46]2[C:45](=[O:47])[N:44]([CH3:48])[CH2:43]3)[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH3:29])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-65b8650175e8451791f11e63d69d71cd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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