反应详情

To a 50 ml round bottom flask equipped with a stir bar and reflux condensor topped with a nitrogen inlet was added 0.5 g (.004 mol) 2,2-dimethyl-5-nitro-5-bromo-1,3-dioxane, 10 ml methanol and 0.3ml concentrated HCl. The reaction was heated to 35°-40° C. for 1 hour. After cooling to room temperature, the volatiles were removed to give crystalline bronopol (95% yield) which on recrystallization from acetone had a melting point of 120° C.

1. customTo a 50 ml round bottom flask equipped with a stir bar
2. temperaturereflux condensor
3. customtopped with a nitrogen inlet
4. temperatureThe reaction was heated to 35°-40° C. for 1 hour
5. customthe volatiles were removed