Water → Tert-butyl 5-[[[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazine-3-carbonyl]amino]methyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

HRID 2324502Notes

Reaction equation

HRID 2324502 reaction equation
[C:51]([CH3:52])([CH3:53])([CH3:54])[O:55][C:56](=[O:57])[N:58]1[C:59]([CH3:65])([CH3:66])[O:60][CH:61]([CH2:63][NH2:64])[CH2:62]1.[CH2:1]([CH2:2][CH2:3][CH3:4])[c:5]1[c:6](-[c:14]2[cH:15][cH:16][c:17]([O:20][CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[cH:18][cH:19]2)[cH:7][c:8]([C:11](=[O:12])[OH:13])[n:9][n:10]1.[CH:67]([N:68]([CH2:69][CH3:70])[CH:71]([CH3:72])[CH3:73])([CH3:74])[CH3:75].[O:76]=[CH:77][N:78]([CH3:79])[CH3:80].[OH2:81].[P-:27]([F:28])([F:29])([F:30])([F:31])([F:32])[F:33].[n:34]1([O:35][C:36]([N:37]([CH3:38])[CH3:39])=[N+:40]([CH3:41])[CH3:42])[c:43]2[cH:44][cH:45][cH:46][cH:47][c:48]2[n:49][n:50]1>>[CH2:1]([CH2:2][CH2:3][CH3:4])[c:5]1[c:6](-[c:14]2[cH:15][cH:16][c:17]([O:20][CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[cH:18][cH:19]2)[cH:7][c:8]([C:11](=[O:13])[NH:64][CH2:63][CH:61]2[O:60][C:59]([CH3:65])([CH3:66])[N:58]([C:56]([O:55][C:51]([CH3:52])([CH3:53])[CH3:54])=[O:57])[CH2:62]2)[n:9][n:10]1

Participants

8

Reactant 7

HCID 962WaterHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 673720716-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acidHCID 67373622Tert-butyl 5-(aminomethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Product 1

HCID 67373731Tert-butyl 5-[[[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazine-3-carbonyl]amino]methyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Sources & evidence

ORD record
ord-154f79eaeb75446ba47a6561c0c8ad44
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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