Tetrahydrofuran → 1-Benzyloxycarbonyl-4-(4-hexyloxyphenyl)-4-hydroxypiperidine

HRID 2325150Notes

Reaction equation

HRID 2325150 reaction equation
[CH2:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[O:23][C:24](=[O:25])[N:26]1[CH2:27][CH2:28][C:29](=[O:32])[CH2:30][CH2:31]1.[CH2:2]([CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]([Br:15])[cH:13][cH:14]1.[Mg:1].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[CH2:2]([CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]([C:29]2([OH:32])[CH2:28][CH2:27][N:26]([C:24]([O:23][CH2:16][c:17]3[cH:18][cH:19][cH:20][cH:21][cH:22]3)=[O:25])[CH2:31][CH2:30]2)[cH:13][cH:14]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 520492Benzene, 1-bromo-4-(hexyloxy)-HCID 643496Benzyl 4-oxopiperidine-1-carboxylateHCID 5462224Magnesium

Product 1

HCID 227131741-Benzyloxycarbonyl-4-(4-hexyloxyphenyl)-4-hydroxypiperidine

Sources & evidence

ORD record
ord-99ad90bd781242d5a23f0c66e222ef6d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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