Imidazole → 5-((tert-butyldimethylsilyloxy)methyl)-1-cyclohexyl-1H-benzo[d]imidazol-2-amine
Reaction equation
[C:24]([CH3:25])([CH3:26])([CH3:27])[Si:28]([CH3:29])([CH3:30])[Cl:31].[CH3:32][N:33]([CH3:34])[CH:35]=[O:36].[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[NH2:1][c:2]1[n:3][c:4]2[c:5]([n:6]1[CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1)[cH:13][cH:14][c:15]([CH2:17][OH:18])[cH:16]2.[nH:19]1[cH:20][cH:21][n:22][cH:23]1>>[NH2:1][c:2]1[n:3][c:4]2[c:5]([n:6]1[CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1)[cH:13][cH:14][c:15]([CH2:17][O:18][Si:28]([C:24]([CH3:25])([CH3:26])[CH3:27])([CH3:29])[CH3:30])[cH:16]2Participants
6
Sources & evidence
- ORD record
- ord-61a85801c4f0443e8d8be3046af8d3c6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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