Hydrochloric Acid → HCID 9842804, compound

HRID 232585Notes

Reaction equation

HRID 232585 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:11][CH2:10][C:9]3([CH2:16][CH2:15][C:14]([CH2:20][CH2:21][CH3:22])([CH2:17][CH2:18][CH3:19])[CH2:13][CH2:12]3)[CH2:8]2)[CH2:3][CH2:2]1.[ClH:23].CCOCC>C(O)C>[ClH:23].[ClH:23].[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:11][CH2:10][C:9]3([CH2:16][CH2:15][C:14]([CH2:20][CH2:21][CH3:22])([CH2:17][CH2:18][CH3:19])[CH2:13][CH2:12]3)[CH2:8]2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 9842805HCID 9842805, compound

Product 1

HCID 9842804HCID 9842804, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2-(4-Piperidinyl)-8,8-dipropyl-2-azaspiro[4.5]decane was dissolved in a minimum of anhydrous ethanol and added to a cooled solution of hydrogen chloride in ethanol. On addition of a large volume of ether, a white precipitate formed which was isolated by filteration. The white solid was recrystallized from ethanol or methanol; mp 298°-300° C.; yield 85-90%.

Workup

  1. customa white precipitate formed which
  2. customwas isolated by filteration
  3. customThe white solid was recrystallized from ethanol or methanol

Sources & evidence

ORD record
ord-a6ea2741b6e54d86bba8c98464b38109
Source dataset
uspto-grants-1997_01
Patent number
US05591748

Reaction notes

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